1) What is alpha lipoic acid and how it is derived?
Lipoic acid also known as α-lipoic acid and alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound derived from octanoic acid. ALA is made in animals normally, and is essential for aerobic metabolism.Lipoic acid is present in almost all foods, but slightly more so in kidney, heart, liver, spinach, broccoli, and yeast extract. Naturally occurring lipoic acid is always covalently bound and not readily available from dietary sources. In addition, the amount of lipoic acid present in dietary sources is very low. For instance, the purification of lipoic acid to determine its structure used an estimated 10 tons of liver residue, which yielded 30 mg of lipoic acid. As a result, all lipoic acid available as a supplement is chemically synthesized.
2) Mechanisms of action and its function
Lipoic acid neutralizes free radicals and associated oxidative cellular damage.Lipoic acid scavenges several reactive oxygen species .Lipoic acid also helps regenerate antioxidant vitamins C and E.In addition, lipoic acid promotes the activity of other antioxidants such as glutathione and coenzyme Q10, which are two essential anti-aging health-promoting compounds .Lipoic acid increases tissue GSH levels, which otherwise decline with age, by restoring glutathione peroxidase activity.Even without dieting, lipoic acid can greatly improve glucose and fat metabolism. As a result, more of the sugars and fats in foods will be broken down and used for energy instead of being stored as fat. This will also cause the consumer to feel the need to eat less. lipoic acid supplementation can protect DNA and cells against exercise-induced oxidative stress , and increase muscle regeneration .Lipoic acid supplementation decreases oxidative damage in the muscles in men who perform muscle-damaging exercises, regardless of whether they are trained or untrained.Abnormal inflammatory responses contribute to diseases such as diabetes, Alzheimer’s disease and multiple sclerosis. Lipoic acid was shown to have an anti-inflammatory effect in subjects with multiple sclerosis, metabolic syndrome , and diabetes.Lipoic acid can reduce inflammatory markers in subjects with organ transplants.Lipoic acid alleviates acute inflammatory responses in animal models .In overweight/obese women, lipoic acid caused a greater reduction the marker of chronic inflammation CRP.In patients with type-2 diabetes, lipoic acid decreases blood glucose and improves insulin sensitivity.People with diabetes are more prone to oxidative stress, which means there is an imbalance of free radicals to antioxidants. Oxidative damage plays a key role in the development of diabetes-associated disorders and diseases.lipoic acid improved systolic blood pressure, dizziness, instability upon standing, leg edema and erectile dysfunction.it improves blood vessels in teem of their elasticity thereby decreases the systolic blood pressure, and indirectly decreases the load on heart.In obese subjects with impaired glucose tolerance, It decreased free fatty acids, triglycerides, total cholesterol, and LDL cholesterol. Lipoic acid also decreased proinflammatory markers and increased adiponectin.It shows antithrombotic affect which inhibit formation of plaque in the artery which blocks the passage for blood flow this condtion is know as atherosclerosis.so highly effective for cardiac health.Generally, you should supplement your diet with 200-400 mg per day.
3)Who can add this as a supplement in their diet?
Those who are doing weight practises, fitness enthusiastic, marathon runner,geriatric population,and it is not less than so called boon for diabetic person which helps to sensitise the insulin and help in maintaning the blood glucose level . In short in it improves the all over helth of an individual.it speed up the return to normal pregnancy conditions and improve the conditions of both the mother and the fetus.The dietary source provides inadequate amount of ALA,which is not proved to be sufficient to elicit the pharmacological responses hence shoud be taken in already synthesized form, the product that are available in HAP STORE are listed below
4) Product available with hap store
1) GNC Alpha Lipoic Acid
2) San ALA
3) Scitech Ala
About the Author – Ravi A Yadav is a registered* pharmacist and a gym enthusiast. He is an expert in weight management and fat loss guidance. He has conducted various fitness workshops in well known institutions & gyms. * Registration Number awaited.
Link:-www.thehapstore.com
Lipoic acid also known as α-lipoic acid and alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound derived from octanoic acid. ALA is made in animals normally, and is essential for aerobic metabolism.Lipoic acid is present in almost all foods, but slightly more so in kidney, heart, liver, spinach, broccoli, and yeast extract. Naturally occurring lipoic acid is always covalently bound and not readily available from dietary sources. In addition, the amount of lipoic acid present in dietary sources is very low. For instance, the purification of lipoic acid to determine its structure used an estimated 10 tons of liver residue, which yielded 30 mg of lipoic acid. As a result, all lipoic acid available as a supplement is chemically synthesized.
2) Mechanisms of action and its function
Lipoic acid neutralizes free radicals and associated oxidative cellular damage.Lipoic acid scavenges several reactive oxygen species .Lipoic acid also helps regenerate antioxidant vitamins C and E.In addition, lipoic acid promotes the activity of other antioxidants such as glutathione and coenzyme Q10, which are two essential anti-aging health-promoting compounds .Lipoic acid increases tissue GSH levels, which otherwise decline with age, by restoring glutathione peroxidase activity.Even without dieting, lipoic acid can greatly improve glucose and fat metabolism. As a result, more of the sugars and fats in foods will be broken down and used for energy instead of being stored as fat. This will also cause the consumer to feel the need to eat less. lipoic acid supplementation can protect DNA and cells against exercise-induced oxidative stress , and increase muscle regeneration .Lipoic acid supplementation decreases oxidative damage in the muscles in men who perform muscle-damaging exercises, regardless of whether they are trained or untrained.Abnormal inflammatory responses contribute to diseases such as diabetes, Alzheimer’s disease and multiple sclerosis. Lipoic acid was shown to have an anti-inflammatory effect in subjects with multiple sclerosis, metabolic syndrome , and diabetes.Lipoic acid can reduce inflammatory markers in subjects with organ transplants.Lipoic acid alleviates acute inflammatory responses in animal models .In overweight/obese women, lipoic acid caused a greater reduction the marker of chronic inflammation CRP.In patients with type-2 diabetes, lipoic acid decreases blood glucose and improves insulin sensitivity.People with diabetes are more prone to oxidative stress, which means there is an imbalance of free radicals to antioxidants. Oxidative damage plays a key role in the development of diabetes-associated disorders and diseases.lipoic acid improved systolic blood pressure, dizziness, instability upon standing, leg edema and erectile dysfunction.it improves blood vessels in teem of their elasticity thereby decreases the systolic blood pressure, and indirectly decreases the load on heart.In obese subjects with impaired glucose tolerance, It decreased free fatty acids, triglycerides, total cholesterol, and LDL cholesterol. Lipoic acid also decreased proinflammatory markers and increased adiponectin.It shows antithrombotic affect which inhibit formation of plaque in the artery which blocks the passage for blood flow this condtion is know as atherosclerosis.so highly effective for cardiac health.Generally, you should supplement your diet with 200-400 mg per day.
3)Who can add this as a supplement in their diet?
Those who are doing weight practises, fitness enthusiastic, marathon runner,geriatric population,and it is not less than so called boon for diabetic person which helps to sensitise the insulin and help in maintaning the blood glucose level . In short in it improves the all over helth of an individual.it speed up the return to normal pregnancy conditions and improve the conditions of both the mother and the fetus.The dietary source provides inadequate amount of ALA,which is not proved to be sufficient to elicit the pharmacological responses hence shoud be taken in already synthesized form, the product that are available in HAP STORE are listed below
4) Product available with hap store
1) GNC Alpha Lipoic Acid
2) San ALA
3) Scitech Ala
About the Author – Ravi A Yadav is a registered* pharmacist and a gym enthusiast. He is an expert in weight management and fat loss guidance. He has conducted various fitness workshops in well known institutions & gyms. * Registration Number awaited.
Link:-www.thehapstore.com
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Its great
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